VASCULAR PHARMACOLOGY


 
STUDY IQB-9302 BUPIVACAINE
Basal tone of isolated aorta No effects at 100 mM contraction
Precontracted aorta wit KCl 35 mM small effects up to 10 mM; relaxant effects at 100 mM small effects up to 10 mM; relaxant effects at 100 mM
Epinephrine precontracted aorta small effects up to 10 mM; relaxant effects at 100 mM small effects up to 10 mM; relaxant effects at 100 mM
Capillary blood flow in volunterss Vasoconstriction Vasodilation
Rat hemodynamics Similar to bupivacaine (slight and non significant higher increase in BP) Similar decrease in HR at 3 mg/kg and higher

Note that concentrations of 100 mM = 0.028 mg/mL may be obtained when solutions of 0.25% (2.5 mg/mL) and higher are locally injected intradermically or near large nerves.