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CURRICULUM VITAE

PERSONAL DATA
Name: Alvaro Galiano Ramos 
DNI: 50.262.039 R
Address: Tebas No. 20 .- Las Rozas (28,230) Madrid) 
Tel:+34 91 631.60.26 ; 606 355 122
e-mail: agaliano@iqb.es 
Birth date: 12/07/1943 

ACADEMIC DATA

Bachilleratos Español y Francés completos 
Madrid 1961-1065. Licenciatura en Ciencias Químicas (Sección Bioquímica y Química Médica). Universidad Complutense. Madrid
Madrid 1995-1996. Master in Multimedia Technology. Facultad de Bellas Artes. Universidad Complutense. Madrid
Ph.D: Faculty of Medicine. Universidad de Córdoba. Argentina

OTHER COURSES

  • Barcelona 1971: Diseño de Fármacos (Drug Design)
  • Madrid 1981: Bioestatistics Workshop (IBM)
  • Basilea 1982: Good Clinical Practices (IPHAR Workshop)
  • Madrid 1982: Screening de Fármacos (Facultad de Veterinaria)
  • Barcelona 1983: CAS-On line workshop (Facultad de C. Quimicas)
  • Madrid 1984: Excerpta Medica workshop (ICYD)
  • Pamplona 1987: Good Laboratory Practices (Universidad de Navarra)
  • Amsterdam 1990: Computer Assisted New Drug Application (Center for Professional Advancement)
  • Madrid, 1992 Master in Biotechnology (primer curso)
  • Informatics: Word processing (WP), databases (Scimate, Pro-cite, etc), Graphics (Coreldraw, Harvard Graphics), Molecular design (Hyperchem), Medline, statistics, etc. Large experience in INTERNET navigation and writting of HTML documents.
  • Madrid, 1997. Workshop on Menopause
  • Madrid, 1997. Workshop on Surgical Techniques in Periodontics
  • Madrid, 1997. Course of 3D-animation (Softimage)
  • Barcelona, 1999: Intensive course of theoric aspects of peripheric system nervous blockage.

  • LANGUAGES

    Good level in spoken and written French and English 
    Italian at conversation level 
    Some knowledge of technical and medical german 

    PROFESSIONAL EXPERIENCE

    • 1970-1975: Technical Director of Laboratorios IQUINOSA (including the areas of production, quality control and research
    • 1972-1973: Stage on the behalf of Iquinosa in The Institute for Arteriosclerosis Research (Culver City, California) owned by Dr. Lester M. Morrison
    • 1975-1979: Consultant of a large number of small and medium-sized spanish pharmaceutical laboratories.
    • 1979-1993: Co-founder, with Laboratorios Berenguer Beneyto, SA y Laboratorios Españoles de Farmacologia Aplicada, del Instituto de Investigación y Desarrollo Químico-Biológico (IQB); General Manager and Technical Manager since its foundation in 1979.
    • 1984: Patent of Oxodipine a new calcium channel blocker (the first once-a-day dihydropyridine)
    • 1985: Joint-venture with DELAGRANGE for the development of Oxodipine
    • 1986: Oxodipine Project is included in the EUREKA program (EU-59)
    • 1987: Patent of Elgodipine a new coronary vasodilator.
    • 1987: Agreement between IQB and Delagrange for cooperation in the context of Plan de Fomento.
    • 1989: Manager of the international project of development of Elgodipine, stopped in phase III (Expected registration, 1999). Elgodipine project was included in the EUREKA program (EU-425)
    • 1993: Rupture of the IQB-DELAGRANGE relationships.
    • 1994: Elgodipine is licenced to Prodesfarma-Almirall GROUP
    • 1994: Development of ENE-ON LINE, the first spanish provider of medical WEBs- Technical Director of ENE-ON  LINE
    • 1995: Development of the Spanish Oncologic WEB of BSK (first spanish medical WEB)
    • 1998-2000: Project manager of  IQB-9302,  a new local anesthetic, sponsored by INIBSA
    • 2000-2001: Development of the WEB-site "Resistencia Insulínica" for Glaxo Smith Kline-Beecham
    • 2012-2016: Development of Dermophyton, new patented cosmeceutic useful in the treatment of recalcitrant pruritus in renal patients under hemodialysis

    PUBLICATIONS

  • Aerosoles basados en agua. Quimica e Industria, 18: 6-14 (1971)
  • Comparison of the cardiac effects of IQB-M-81(*) and lignocaine. Br.J.Pharmacol., 77: 465P (1982)
  • Farmacocinética de la N-acetil-homocisteina. I. Niveles plasmáticos después de la administración oral en la rata. Ciencia e Industria Farmaceútica, 2: 45-47 (1983)
  • Asma broquial y Reproterol. Geriatrics, 5: 41-48 (1985)
  • Situación actual en el tratamiento de las Hepatopatias. En Aspectos Bioquimicos y Farmacológicos en disfunciones hepáticas.Ed. Consejo Superior de Investigaciones Cientificas, Madrid, 1987 pags 59-84
  • Cadórniga, R., Barcia, E., Molina, I.T., Galiano, A.,Gutierrez, J.A. Estudio Farmacocinético de la Guanil-cisteina. Rev.Farmacol.Clin.Exp.(1987) 4(4): 325-331
  • Galiano, A. Oxodipine. Drugs of the Future (1987) 12(7): 633-635
  • Moratalla, R., Romera, R., Galiano, A. Pharmacological Study of the New Mucolytic Drug N-Guanyl-cysteine. Arzneim.-Forsch./Drug Res.(1986) 36 (I), 6: 918-923.
  • Nyska, A., Waner, T., Pirak, M., Galiano, A., Zlotogorski, A. Gingival hyperplasia in rats induced by oxodipine, a calcium channel blocker. J.Periodontol.Res.(1990) 25: 65-68
  • Nyska, A., Waner, T., Zlotogorski, A., Pirak, M., Scolnik, M., Nyska, M., Galiano, A. Oxodipine-induced gingival hyperplasia in beagle dogs. American Journal of Pathology (1990) 137(3): 737-739
  • Waner, T., Nyska, A., Nyska, M., Pirak, M., Sela, M., Galiano, A. Gingival Hyperplasia in Dogs Induced by Oxodipine a calcium channel blocking agent. Toxicologic Pathology (1988) 16 (3): 327-332.
  • Waner, T., Nyska, A., Galiano, A. Drug-induced decrease of serum-alanine and aspartate amino tranferase in the rat. J.Clin.Chem. (1990) 28, 25-30
  • Nyska, A., Waner, T., Shapira, S., Skutelski, E., Galiano, A., Dayan, D. Thickening of the adrenal zona glomerulosa in dogs induced by oxodipine, a calcium channel blocker. Toxicologic Pathology, (1992) 20 (4): 549-555
  • Montastruc, P., Montastruc, Dubreuil, J., Galiano, A. Effect of Oxodipine, a new calcium entry blocker in acute neurogenic hypertension in dogs. Archives Internationales de Pharmacodynamie et Thérapie, 321, 57-62 (1993)
  • Acharya, D.U., Senior, R., Basu, S., Harrison, F., Galiano A. Lahiri, A : Anti-ischemic and hemodynamic effects of Elgodipine, a potent new generation calcium antagonist, in chronic stable angina" European Heart Journal, 15, 665-671 (1994)
  • Harrison J.J., Hierler, F., Scherer, J., Wulsh, A, Galiano, A., Hornauer, M., Kelly, J.: Study of Pharmacokinetics of pharmacodynamics of two preparations of Metoclopramide. Arzneim-Forsch, 44 (4): 519-521 (1994)
  • Mironneau, J., Lepretre, N., Arnaudeau, S., Rakoroarisoa, L., Galiano, A. Electrophysiological and radioligand binding studies of Elgodipine and derivatives in portal vein myocytes. Journal of Pharmacology and Experimental Therapeutics, 271 (3): 1209-1215. (1994)
  • Platonoff, N., Millart, H., Leperre, A., Galiano A., Kantelip, J.P. Comparative effects of Oxodipine and Nifedipine on contractility and intracellular pH and calcium concentration in cultured newborn rat cardiac cells. Archives Internationales de Pharmacodynamie et Thérapie (to be published)
  • Rakotoarisoa, L., Mironneau, J., Galiano, A., Mironneau, C: Effects of Oxodipine and Elgodipine on (+)-3H-isradipine binding and vascular membranes: cardiovascular selectivity. Fundamental and Clinical Pharmacology , 8 : 546-552 (1994)
  • Galiano, A., de la Motte, S., Hornauer, M., Kelly, J., Harrison F. A preliminary investigation of the pharmacodynamics, pharmacokinetics and renal excretion of different oral doses of elgodipine in normal subjects. (To be published)
  • Galiano, A: Elgodipine. Drugs of the Future  20 (3) 231-234(1995)
  • A Ruiz-Nuño, J.M.Hernández-Guijo, A.Galiano, A.G.García, L. Gandía. Blockade of neuronal voltage-dependent Na+ channels by a novel local anaesthetic. To be published 
  • Gomez De Segura IA, Vazquez Moreno-Planas I, Benito J, Galiano A, De Miguel E. Electrophysiologic cardiac effects of the new local anesthetic IQB-9302 and of bupivacaine in the anesthetised dog. Acta Anaesthesiol Scand . 2002 Jul;46(6):666-73.
  • Gálvez-Múgica MA, Santos-Ampuero MA, Novalbos J, Gallego Sandín S, Galiano A, Gilsanz F, García AG, Abad-Santos F. Ulnar nerve block induced by the new local anesthetic IQB-9302 in healthy volunteers: a comparison with bupivacaine. Anesth Analg. 2001 Nov;93(5):1316-20.
  • A Galiano: Estudios de toxicidad. En "El Ensayo Clínico en España" Una publicación de Farmaindustria. (Julio 2001)

MULTIMEDIA CD-ROMS and WORKSHOPS

BOOKS

    1995: Drug Treatment of hepatic diseases
    2000: Toxicological Studies in NDA. Universidad Menéndez Pelayo (Santander, Spain) A chapter o the book "Clinical Studies" Ed.Farmaindutria.
    2011: Aerosoles anticolinérgicos: In Inhaloterapia. Ed. William Cristancho.

MEDICAL WEBS 

    1995: Oncology (Beecham Smith-Kline)
    1998: Pensa Médica
    1999: GESIDA
    1999: Antibióticos Pharma
    2000-2001: Resistencia Insulinica (Glaxo Smith-Kline)
    2000-2017: Medciclopedia (www.iqb.es)
    2011: www.pruritus.es
    2017: www.iqb.es reached >230 million of unique visitors


    PATENTS

    Spanish Patent 443457 (Dic. 1975) Procedimiento perfeccionado para la obtención la 21-hidroxibenzoil-triamcinolona.

    Spanish Patent 467362 (sep.1978) Procedimiento de obtención de antibióticos alfa-amino-fenilacetamido beta-lactámicos n-alquil sustituidos

    Spanish Patent 332.004.9 enlarged to Germany, Austria, Belgium, Canada, France, United Kingdom, The Netherlands, Italy, Japan y Sweden (Pincainide, local anesthetic-antiarrhythmic)

    Spanish Patents 531.033 and 536.537 World-wide enlarged (Oxodipine)

    European Patent 87 004 193.6 (New Imizadol antifungal derivatives)

    European Patent 87 401 799.9 (Elgodipine)

    European Patent 90 100 232.9 (New free radical scavengers)

    Spanish Patent P-9200051 (New hydrazones with antiproliferative activity - Tyrosine Kinase inhibitors)

    Spanish Patent P-9302303 (New local anesthetics) world-wide enlarged as PCT ES94/00107

    Spanish Patent P201201001 (2015): Esential oils and terpenes as moduladors of Transient Potential Receptors


    COMMUNICATIONS TO CONGRESSES

    Torremolinos, 1980: Synthesis and analgesic activity of new azabicyclospirohydantoins N- substituted. VII International Symposium on Medicinal Chemistry

    Toulouse 1981: Estudio Farmacológico del IQB-872, un nuevo mucolitico. VI Reunión Nacional de la Asociación de Farmacológos

    Salamanca 1982: Farmacocinética de la Guanil-cisteina en la rata y el conejo. VII reunión Nacional de la Asociación de Farmacológos

    Salamanca 1982: Farmacocinética del Sarmecillinam, un nuevo antibiótico beta-lactámico. VII reunión Nacional de la Asociación de Farmacólogos

    Salamanca 1982: Farmacolog¡a del IQB-M-81, un nuevo anestésico local. VII Reunión Nacional de la Asociación de Farmacólogos.

    Budapest, 1984: Mise au point de méthodes de dosage de nouvelles 2,5-benzoxazocines substituées dans le plasma. Applications pharmacocinétiques: traitement sur ordinateur des Resultats. International Congress of Pharmaceutical Sciences

    Uppsala, 1984: New 1,4-dihydropyridines as calcium antagonists and antihypertensive agents. VIII International Symposium of Medicinal Chemistry

    Salamanca 1984: Absorción digestiva de Guanil-ciste¡na. IX Reunión Nacional de la Asociación de Farmacólogos.

    Fribourg, 1987: In vitro dissolution studies of oxodipine and pharmacokinetics in laboratory animals. III International Congress of Pharmacokinetics and Biopharmacy

    Bilbao, 1987: Efectos de la oxodipina en ratas hipertensas. XII Reunión Nacional de la Asociación de Farmacólogos

    Montpellier, 1987: Oxodipine, a new antihypertensive agent; study between effect and pharmacokinetic model applied to humans. 3émes Journées Méditerranéennes de Pharmacocinétique

    Montpellier, 1987: Etude de la relation entre effet et modéle pharmacocinétique appliquée chez l'homme par un nouvel antihypertensif: l'oxodipine. 3émes Journées Méditerranéennes de Pharmacocinétique

    Basel, 1988: Pharmacological studies of the antihypertensive effect of oxodipine. 1st International Symposium of Calcium Antagonists

    Basel, 1988: Oxodipine, a new antihypertensive dihydropyridine: pharmacokinetic and pharmacodynamic relationships in man. 1st International Symposium of Calcium Antagonists

    Basel, 1988: Oxodipine, a new antihypertensive dihydropyridine: pharmacokinetics after repeated oral doses in relation to the effect.1st International Symposium of Calcium Antagonists

    Basel, 1988: Cardiac electrophysiological effects of Oxodipine in the unanestatized dog. Comparison with nifedipine. 1st International Symposium of Calcium Antagonists

    Basel, 1988: Determination of Clinical Tolerance of 20 mg daily doses of oxodipine (IQB-837) in six male volunteers during a period of 8 days. 1st International Symposium of Calcium Antagonists

    Munich 1988: Recovery from gingival hyperplasia induced by oxodipine, a calcium channel blocker. III International Congress on Toxicology

    Murcia 1988: Nuevas 1,4-dihidropiridinas como antagonistas del calcio. XIII Reunión Nacional de la Asociación de Farmacólogos.

    Bilbao 1988: Efecto hemodinámico de dos nuevas dihidropiridinas, IQB-872D e IQB-875D en el perro anestesiado. XXI Congreso Nacional de Cardiolog¡a

    Eilat, 1989: Common side effects on calcium antagonists in laboratory animals. 2nd International Conference on Calcium Antagonists

    Tokyo, 1989: The antithrombotic, thrombolytic and vasoprotective effect of Oxodipine, a new calcium antagonist. 12th Int.Cong.Throm.Haemost.

    Badajoz, 1989: Estudio hemodinámico de la elgodipina en rata, perro y cerdo. XIV Reunión Nacional de la Asociación de Farmacólogos

    Amsterdam, 1990: Effects of elgodipine in vascular smooth muscles. 11st Int.Congres Pharmacology

    Amsterdam, 1990: Elgodipine vs. nicardipine: hemodynamic changes in anesthetized dogs. 11st Int.Congress Pharmacol.

    Amsterdam, 1990: Study of the agonism and antagonism of elgodipine on different types of receptors. 11st Int.Congress Pharmacol.

    Basel, 1991: Antihypertensive activity of oxodipine, a new dihydropyridine calcium blocker. Tolerance and dose-effect relationship determination. 5th Int.Symp.Calcium Antagonists.

    Benalmádena (Málaga) (1992): Valoración de captadores de radicales libres mediante el modelo de cardiotoxicidad. Rev.farm.clin.exp. 1992 Número  especial

    Montreal (1994): Pharmacology of a new potent local anesthetic. 15th Int.Congress Pharmacol.

    Amsterdam, 1994. Anti-ischemic and Haemodynamic Effects of elgodipine: a new calcium antagonist. Int. Congress  Cardiology, 

    Paris (1995). Pharmacokinetics and pharmacodynamics of different oral doses of Elgodipine in normal subjects. 1st Congress of the European Association for Clinical Pharmacology and Therapeutics. Abst 470   

    Lisboa (2000): Blockage of neuronal, voltage-dependent Na-Channels by the Novel Local Anesthetic, IQB-9302 (Abst 09-010)

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